Which statement is true about cannabinoids?

Cannabinoids, which are compounds found in cannabis, can indeed lead to tolerance, withdrawal, and dependence in some individuals. This is particularly true with regular and heavy use. Over time, a person may need to consume larger amounts to achieve the same effects (tolerance). Additionally, when a long-term user tries to stop or cut back on use, they may experience withdrawal symptoms, which can include irritability, cravings, insomnia, and changes in appetite. These aspects indicate that cannabinoids can have addictive properties similar to other substances, reflecting the complexity of their impact on users.

The other statements do not accurately represent the broader understanding of cannabinoids. While they can have a range of effects, they are not exclusively categorized as depressants. Negative health effects associated with cannabis use, such as impaired cognitive function and respiratory issues, have been documented. Moreover, the legal status of cannabinoids varies significantly across different states in the U.S., with some regions allowing recreational and medicinal use while others maintain strict prohibitions. This contextual understanding of cannabinoids helps clarify the reason why the statement about tolerance, withdrawal, and dependence is accurate.